Duan Y
102nd Hospital of Chinese PLA.
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Apr;23(2):75-8, 125-6.
The thyrotrophin (TSH) response to thyrotrophin-releasing hormone (TRH) 300 micrograms intravenously was studied in 25 patients with schizophrenia, 14 with depression, and 8 with mania. The rate of blunted TRH test results was zero in healthy controls, 64.3% in depression, 62.5% in mania, and 28.0% in schizophrenia. These differences of the rates between depression or mania patients and controls were significant, whereas the difference of rates between schizophrenias and healthy controls was not significant by X2 test. These results seemed to support the view that TRH stimulation test can be used as a biological marker to distinguish affective disorder and that both depression and mania is correlated with the decreased function of serotonin.
对25例精神分裂症患者、14例抑郁症患者和8例躁狂症患者静脉注射300微克促甲状腺激素释放激素（TRH）后促甲状腺激素（TSH）的反应进行了研究。健康对照组TRH试验结果迟钝率为零，抑郁症患者为64.3%，躁狂症患者为62.5%，精神分裂症患者为28.0%。经X²检验，抑郁症或躁狂症患者与对照组之间的迟钝率差异有统计学意义，而精神分裂症患者与健康对照组之间的迟钝率差异无统计学意义。这些结果似乎支持这样一种观点，即TRH刺激试验可作为区分情感障碍的生物学标志物，且抑郁症和躁狂症均与血清素功能降低有关。
