Kirstein L, Gold M S, Pottash A L, Extein I
Biol Psychiatry. 1981 Sep;16(9):819-24.
Change in maximal TSH response to a TRH infusion were measured in 18 unipolar depressed males and 2 control groups matched for age, sex, and base-line thyroid status. The mean maximal change in TSH response was significantly lower for the unipolar than the control groups. Clinical and research implications of these findings are discussed. By using a deltaTSH cutoff of 7.0 rather than 5 microIU/ml, 14 rather than 7 depressed patients were correctly identified as having a blunted deltaTSH; 29 rather than 32 to 36 control patients were correctly identified as having a normal deltaTSH score.
在18名单相抑郁男性患者以及与他们年龄、性别和基线甲状腺状态相匹配的2个对照组中，测量了促甲状腺激素释放激素（TRH）输注后促甲状腺激素（TSH）的最大反应变化。单相抑郁患者TSH反应的平均最大变化显著低于对照组。文中讨论了这些发现的临床和研究意义。通过使用7.0而非5微国际单位/毫升的促甲状腺激素变化值（deltaTSH）临界值，正确识别出14名而非7名抑郁患者的deltaTSH反应迟钝；正确识别出29名而非32至36名对照患者的deltaTSH评分正常。
