Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer's Disease Research, Center FOR HER (Focused On Resources for her Health, Education and Research), University of North Texas Health Science Center, Fort Worth, TX, USA
Ther Adv Neurol Disord. 2009 Jan;2(1):13-29. doi: 10.1177/1756285608100325.
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Demyelinization of nerve fibres not only affects the motor and sensory systems functionally, but may also cause psychopathological signs and symptoms. In addition to the psychiatric manifestations of MS, many patients have reactive psychological problems that are often hard to distinguish from the 'organic' causation of psychopathology. In any event, psychiatric comorbidity in MS deserves greater clinical attention than has been previously paid, because the presence of psychopathology may have deleterious effects on the disease process and impair coping with disability.
多发性硬化症（MS）是一种中枢神经系统的慢性炎症性疾病。神经纤维的脱髓鞘不仅会影响运动和感觉系统的功能，还可能导致精神病理学的迹象和症状。除了多发性硬化症的精神表现外，许多患者还存在反应性心理问题，这些问题常常难以与精神病理学的“器质性”病因区分开来。无论如何，多发性硬化症的合并症在临床上需要比以前更受关注，因为精神病理学的存在可能对疾病过程产生有害影响，并影响对残疾的应对能力。
