亚甲基四氢叶酸还原酶（MTHFR）基因多态性与头颈部鳞状细胞癌的风险。
Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and risk of head and neck squamous cell carcinoma.
机构信息
Centro Nacional de Desenvolvimento Científico e Tecnológico, Brazil.
出版信息
Braz J Otorhinolaryngol. 2010 Nov-Dec;76(6):776-82. doi: 10.1590/S1808-86942010000600017.
UNLABELLED
Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis.
AIM
To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters. SERIES AND METHODS: A retrospective study that assessed gender, age, tobacco, alcohol consumption and clinical histopathological parameters in 200 patients (100 with disease and 100 with no history of cancer). PCR-RFLP molecular analysis was carried out and the chi-square test and multiple logistic regression were applied for the statistical analysis.
RESULTS
There was no association between MTHFR C677T polymorphism and head and neck cancer (p = 0.50). Significant differences between the study and control groups were observed at age over 50 years, tobacco use, and male gender (p <0.001). There was no association of disease with clinical-histopathological parameters.
CONCLUSION
No association between the MTHFR C677T polymorphism and head and neck squamous cell carcinoma was possible in this study.
未加标注
亚甲基四氢叶酸还原酶基因（MTHFR）C677T 多态性可能是头颈部鳞状细胞癌的危险因素，因为叶酸水平的变化会导致甲基化途径紊乱，从而导致癌变。
目的
评估头颈部鳞状细胞癌患者和无癌症史个体中 MTHFR C677T 多态性，并评估该疾病与临床组织病理学参数的相关性。
系列和方法
回顾性研究评估了 200 名患者（100 名患有疾病，100 名无癌症史）的性别、年龄、烟草、酒精消费和临床组织病理学参数。进行了 PCR-RFLP 分子分析，并应用卡方检验和多因素逻辑回归进行了统计学分析。
结果
MTHFR C677T 多态性与头颈部癌症之间无关联（p=0.50）。在年龄超过 50 岁、吸烟和男性方面，研究组和对照组之间存在显著差异（p<0.001）。疾病与临床组织病理学参数之间无关联。
结论
在本研究中，MTHFR C677T 多态性与头颈部鳞状细胞癌之间不存在关联。
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