新型局部麻醉剂氨基甲酸酯衍生物卡比卡因、庚卡因和喷他卡因的遗传毒理学研究。
A genotoxicological study of the new local anaesthetic carbamate derivatives carbisocaine, heptacaine and pentacaine.
作者信息
Siekel P
机构信息
Institute of Biochemistry and Biotechnology, Comenius University, Bratislava, Czechoslovakia.
出版信息
J Appl Toxicol. 1990 Aug;10(4):239-43. doi: 10.1002/jat.2550100403.
PMID:2118149
Abstract
The potential mutagenic activity of three carbamate derivatives with local anaesthetic activity was investigated. Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis, whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimurium, Escherichia coli and Drosophila melanogaster.
摘要
研究了三种具有局部麻醉活性的氨基甲酸酯衍生物的潜在诱变活性。在纤细裸藻上施用卡比佐卡因后观察到遗传毒性活性，而卡比佐卡因、庚卡因和喷他卡因在鼠伤寒沙门氏菌、大肠杆菌和黑腹果蝇上未检测到活性。
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