Kandrotas R J, Love J M, Gal P, Oles K S
Moses H. Cone Memorial Hospital, Greensboro, NC.
Neurology. 1990 Sep;40(9):1456-8. doi: 10.1212/wnl.40.9.1456.
We report a patient with dialysis-induced encephalopathy who was taking divalproex sodium for a seizure disorder. Her serum valproic acid concentration appeared to be in the low therapeutic range at 54 mg/l yet she continued to have seizure activity. The elimination half-life and apparent clearance of valproic acid were the same for both a dialysis and nondialysis day, indicating that hemodialysis/hemoperfusion has little effect on the overall removal of valproic acid from the body.
我们报告了一名患有透析性脑病的患者，该患者因癫痫障碍正在服用丙戊酸二钠。她的血清丙戊酸浓度似乎处于54毫克/升的低治疗范围内，但她仍有癫痫发作活动。透析日和非透析日丙戊酸的消除半衰期和表观清除率相同，这表明血液透析/血液灌流对丙戊酸从体内的整体清除影响很小。
