MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China.
FEBS J. 2011 Feb;278(3):403-13. doi: 10.1111/j.1742-4658.2010.07965.x. Epub 2010 Dec 23.
Autophagy and apoptosis play important roles in the development, cellular homeostasis and, especially, oncogenesis of mammals. They may be triggered by common upstream signals, resulting in combined autophagy and apoptosis. In other instances, they may be mutually exclusive. Recent studies have suggested possible molecular mechanisms for crosstalk between autophagy and apoptosis. Bcl-2 and Bcl-xL, the well-characterized apoptosis guards, appear to be important factors in autophagy, inhibiting Beclin 1-mediated autophagy by binding to Beclin 1. In addition, Beclin 1, Bcl-2 and Bcl-xL can cooperate with Atg5 or Ca(2+) to regulate both autophagy and apoptosis. Thus, Bcl-2 and Bcl-xL represent a molecular link between autophagy and apoptosis. Here, we discuss the possible roles of Bcl-2 and Bcl-xL in apoptosis and autophagy, and the crosstalk between them.
自噬和细胞凋亡在哺乳动物的发育、细胞内稳态，尤其是肿瘤发生中起着重要作用。它们可能由共同的上游信号触发，导致自噬和细胞凋亡的联合发生。在其他情况下，它们可能是相互排斥的。最近的研究提出了自噬和细胞凋亡之间相互作用的可能分子机制。Bcl-2 和 Bcl-xL，即众所周知的凋亡保护因子，似乎是自噬的重要因素，通过与 Beclin 1 结合抑制 Beclin 1 介导的自噬。此外，Beclin 1、Bcl-2 和 Bcl-xL 可以与 Atg5 或 Ca(2+) 合作调节自噬和细胞凋亡。因此，Bcl-2 和 Bcl-xL 代表了自噬和细胞凋亡之间的分子联系。在这里，我们讨论了 Bcl-2 和 Bcl-xL 在细胞凋亡和自噬中的可能作用，以及它们之间的相互作用。
