He Zefeng, Liu Jing, Jin Qianxu, Ren Shangkun, Liu Liang, Liu Yingzi
Neurosurgery Department, The 4th Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Front Oncol. 2025 Jun 4;15:1588598. doi: 10.3389/fonc.2025.1588598. eCollection 2025.
Glioma is the most common primary tumor of the central nervous system, with glioblastoma being its predominant pathological type. In recent years, research has demonstrated that ion channels are intricately linked with numerous biological processes in tumor cells, including apoptosis and migration, among others. This study employs bibliometric analysis to systematically examine and synthesize the knowledge structure and research focal points in the field of glioblastoma ion channels. Publications related to ion channels in glioblastoma, published between January 1, 2005 and December 31, 2024, were retrieved from the Web of Science Core Collection (WoSCC). The dataset comprises 764 articles and 234 reviews. Utilize VOSviewer, CiteSpace, Bibliometrix, and Excel to conduct an in-depth analysis and visualization of scholarly contributions based on country, institution, journal, and author. Additionally, examine highly cited publications, references, and keywords. From 2005 to 2024, the number of publications in this field has shown a consistent annual increase. The University of Alabama and Cancer are among the leading institutions and journals. Sontheimer Harald, from the United States, is the most prolific author in this field. The analysis of highly cited publications and co-cited references indicates that the research background and foundation focus on elucidating the mechanisms by which ion channels influence the onset and progression of glioblastoma. Keyword analysis indicated that "tumor microenvironment" (burst strength: 4. 67), "Ca activated K channel" (burst strength: 3. 98), and "chloride channels" (burst strength: 3. 59) have been the keywords exhibiting the highest burst intensity over the past two decades. The keywords that have emerged with higher frequency in the past five years include "tumor microenvironment" (burst strength: 4. 67), "receptor" (burst strength: 3. 11), and "channels" (burst strength: 3. 11). Research on ion channels in glioblastoma has emerged as a prominent and rapidly evolving field of interest. Previous studies have primarily focused on the examination of specific ion channels and their functionalities. However, recent keyword analysis highlights the necessity to explore the interaction between ion channels and the tumor microenvironment. Meanwhile by integrating single-cell spatial transcriptomics and nanoparticle technologies, we can significantly enhance the efficacy of ion channel-targeting therapies.
胶质瘤是中枢神经系统最常见的原发性肿瘤，胶质母细胞瘤是其主要的病理类型。近年来，研究表明离子通道与肿瘤细胞中的许多生物学过程密切相关，包括细胞凋亡和迁移等。本研究采用文献计量分析方法，系统地审视和综合胶质母细胞瘤离子通道领域的知识结构和研究重点。从科学网核心合集（WoSCC）中检索了2005年1月1日至2024年12月31日期间发表的与胶质母细胞瘤离子通道相关的出版物。该数据集包括764篇文章和234篇综述。利用VOSviewer、CiteSpace、Bibliometrix和Excel，基于国家、机构、期刊和作者对学术贡献进行深入分析和可视化。此外，还对高被引出版物、参考文献和关键词进行了研究。2005年至2024年期间，该领域的出版物数量呈逐年稳步增长态势。阿拉巴马大学和《癌症》分别是领先的机构和期刊。来自美国的桑特海默·哈拉尔德是该领域发文量最多的作者。对高被引出版物和共被引参考文献的分析表明，研究背景和基础集中在阐明离子通道影响胶质母细胞瘤发生和发展的机制上。关键词分析表明，“肿瘤微环境”（突发强度：4.67）、“钙激活钾通道”（突发强度：3.98）和“氯离子通道”（突发强度：3.59）是过去二十年中突发强度最高的关键词。过去五年中出现频率较高的关键词包括“肿瘤微环境”（突发强度：4.67）、“受体”（突发强度：3.11）和“通道”（突发强度：3.11）。胶质母细胞瘤离子通道的研究已成为一个突出且发展迅速的热门领域。以往的研究主要集中在对特定离子通道及其功能的研究上。然而，最近的关键词分析凸显了探索离子通道与肿瘤微环境之间相互作用的必要性。同时，通过整合单细胞空间转录组学和纳米颗粒技术，我们可以显著提高离子通道靶向治疗的疗效。
