Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Infect Genet Evol. 2011 Mar;11(2):528-31. doi: 10.1016/j.meegid.2010.12.002. Epub 2010 Dec 21.
The merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses.
裂殖子表面蛋白（MSP）家族参与疟原虫与红细胞的初始相互作用，因此其成员成为疫苗开发的主要目标。考虑到亚单位疟疾疫苗中包含的抗原既应能被免疫系统识别，又应缺乏遗传多样性或具有非常有限的多态性，我们分析了哥伦比亚不同地理区域的三种 msp 基因（msp-7A、msp-7K 和 msp-10）的遗传多样性。结果表明，这些基因遵循中性进化模式，遗传多样性也较低。在来自地理位置不同地区的分离株中发现 msp-7 单倍型具有很强的保守性，这进一步表明这些蛋白可能是对抗间日疟原虫疟疾疫苗的良好成分，从而避免针对特定菌株的免疫反应。
