Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Placenta. 2011 Feb;32(2):175-82. doi: 10.1016/j.placenta.2010.11.014. Epub 2010 Dec 22.
The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n = 60) set of human placentas in order to uncover gene expression patterns associated with preeclampsia. In addition to confirming changes in expression of soluble factors associated with preeclampsia such as sFLT1 (soluble fms-like tyrosine kinase-1), sENG (soluble endoglin), and INHA (inhibin alpha), we also find changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeclampsia. Notably, we also find evidence of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases.
胎盘在胎儿营养和生长的调节中起着重要作用，贯穿整个发育过程，胎盘因素导致妊娠异常，如子痫前期。本研究描述了一大组（n=60）人类胎盘的全基因组基因表达谱，以揭示与子痫前期相关的基因表达模式。除了确认与子痫前期相关的可溶性因子（如 sFLT1（可溶性 fms 样酪氨酸激酶-1）、sENG（可溶性内皮糖蛋白）和 INHA（抑制素 alpha））表达变化外，我们还发现免疫相关信号通路的变化，为子痫前期发病机制中通常观察到的浅绒毛膜浸润和子宫重塑不足提供了潜在的上游解释。值得注意的是，我们还发现子痫前期相关的胎盘上调唾液酸乙酰酯酶（SIAE）的证据，SIAE 是一个与自身免疫性疾病功能相关的基因。
