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枯草芽孢杆菌亚种 spizizenii gtP20b 的基因组序列,该菌分离自印度洋。

Genome sequence of Bacillus subtilis subsp. spizizenii gtP20b, isolated from the Indian ocean.

机构信息

Department of Molecular Phytopathology, Christian-Albrechts-University of Kiel, Hermann, Kiel, Germany.

出版信息

J Bacteriol. 2011 Mar;193(5):1276-7. doi: 10.1128/JB.01351-10. Epub 2010 Dec 23.

DOI:10.1128/JB.01351-10
PMID:21183663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3067579/
Abstract

Bacillus subtilis is an aerobic spore-forming Gram-positive bacterium that is a model organism and of great industrial significance as the source of diverse novel functional molecules. Here we present, to our knowledge, the first genome sequence of Bacillus subtilis strain gtP20b isolated from the marine environment. A subset of candidate genes and gene clusters were identified, which are potentially involved in production of diverse functional molecules, like novel ribosomal and nonribosomal antimicrobial peptides. The genome sequence described in this paper is due to its high strain specificity of great importance for basic as well as applied researches on marine organisms.

摘要

枯草芽孢杆菌是一种需氧、产芽孢的革兰氏阳性菌,它是一种模式生物,也是一种具有重要工业意义的微生物,因为它是多种新型功能分子的来源。在这里,我们展示了一株从海洋环境中分离得到的枯草芽孢杆菌菌株 gtP20b 的基因组序列,这是我们所知的首例。我们鉴定了一组候选基因和基因簇,它们可能参与了多种功能分子的产生,如新型核糖体和非核糖体抗菌肽。本文所描述的基因组序列因其菌株特异性高,对于海洋生物的基础研究和应用研究都具有重要意义。

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本文引用的文献

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Understanding the evolutionary relationships and major traits of Bacillus through comparative genomics.通过比较基因组学了解芽孢杆菌的进化关系和主要特征。
BMC Genomics. 2010 May 26;11:332. doi: 10.1186/1471-2164-11-332.
2
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BMC Genomics. 2010 Apr 16;11:243. doi: 10.1186/1471-2164-11-243.
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CAMP: a useful resource for research on antimicrobial peptides.CAMP:研究抗菌肽的有用资源。
Nucleic Acids Res. 2010 Jan;38(Database issue):D774-80. doi: 10.1093/nar/gkp1021. Epub 2009 Nov 18.
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From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.从群体序列到统一序列:十年后的枯草芽孢杆菌168参考基因组
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Diversity and phylogeny of culturable spore-forming Bacilli isolated from marine sediments.从海洋沉积物中分离出的可培养产芽孢杆菌的多样性和系统发育
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APD2: the updated antimicrobial peptide database and its application in peptide design.APD2:更新后的抗菌肽数据库及其在肽设计中的应用。
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