Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
J Clin Invest. 2011 Jan;121(1):31-3. doi: 10.1172/JCI45758. Epub 2010 Dec 22.
The blood-brain barrier (BBB) presents a significant obstacle to delivery of targeted therapies to brain tumors. In this issue of the JCI, Staquicini and colleagues apply an in vivo phage-displayed library of random peptides to identify differentially expressed peptides that can be used to transport targeted agents across the intact BBB. The authors uncover a non-canonical, peptide-mediated iron-mimicry mechanism to induce transport of the transferrin/transferrin receptor complex across the BBB. They then demonstrate the ability of phage-targeting approaches to deliver therapeutic cargo and molecular imaging reporters across the BBB in an intracranial glioblastoma mouse model.
血脑屏障（BBB）对靶向治疗脑肿瘤的药物输送构成了重大障碍。在本期 JCI 中，Staquicini 及其同事应用体内噬菌体展示随机肽文库来鉴定可用于将靶向药物输送穿过完整 BBB 的差异表达肽。作者发现了一种非经典的、肽介导的铁模拟机制，可诱导转铁蛋白/转铁蛋白受体复合物穿过 BBB 进行转运。然后，他们证明了噬菌体靶向方法在颅内胶质母细胞瘤小鼠模型中穿过 BBB 传递治疗性货物和分子成像报告物的能力。
