J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.
Adv Drug Deliv Rev. 2021 Mar;170:238-260. doi: 10.1016/j.addr.2021.01.008. Epub 2021 Jan 20.
A grand challenge in drug delivery is providing the right dose, at the right anatomic location, for the right duration of time to maximize therapeutic efficacy while minimizing off-target toxicity and other deleterious side-effects. Two general modalities are receiving broad attention for localized drug delivery. In the first, referred to as "targeted accumulation", drugs or drug carriers are engineered to have targeting moieties that promote their accumulation at a specific tissue site from circulation. In the second, referred to as "local anchoring", drugs or drug carriers are inserted directly into the tissue site of interest where they persist for a specified duration of time. This review surveys recent advances in harnessing molecular recognition between proteins, peptides, nucleic acids, lipids, and carbohydrates to mediate targeted accumulation and local anchoring of drugs and drug carriers.
药物输送中的一个重大挑战是提供正确的剂量，在正确的解剖位置，在正确的时间内，以最大限度地提高治疗效果，同时最小化脱靶毒性和其他有害的副作用。有两种一般的方法正在受到广泛关注，用于局部药物输送。在第一种方法中，称为“靶向积累”，药物或药物载体被设计成具有靶向部分，以促进其从循环中在特定组织部位积累。在第二种方法中，称为“局部锚定”，药物或药物载体直接插入到感兴趣的组织部位，在那里它们持续特定的时间。这篇综述调查了利用蛋白质、肽、核酸、脂质和碳水化合物之间的分子识别来介导药物和药物载体的靶向积累和局部锚定的最新进展。
