The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing, China.
Lab Chip. 2011 Feb 21;11(4):652-7. doi: 10.1039/c0lc00463d. Epub 2010 Dec 24.
In this work, we describe a novel and simple microfluidic method for fabricating nanoparticle-coated chitosan microspheres. Uniform droplets of aqueous chitosan solution were dispersed into an oil phase containing partially hydrophilic nanoparticles via a co-axial microfluidic device. Recirculating flow in the continuous phase in the area between drops enhanced mixing and allowed the nanoparticles to coat the surface of the droplets as they passed through the channel. The chitosan droplets were then crosslinked with glutaraldehyde and nanoparticle-coated microspheres were obtained. SEM characterization shows that the microspheres are monodispersed with uniform nanoparticle distribution on the surface. The dispersity, size and composition of the microspheres could all easily be controlled by changing the microfluidic flow parameters and three different types of nanoparticles were successfully used to synthesize hybrid microspheres to demonstrate the method's versatility.
在这项工作中，我们描述了一种新颖而简单的微流控方法，用于制备纳米粒子包覆壳聚糖微球。通过同轴微流控装置，将含有部分亲水性纳米粒子的水相壳聚糖溶液分散成均匀的液滴。在液滴之间的连续相区域内的循环流动增强了混合，并允许纳米粒子在穿过通道时包覆液滴的表面。然后用戊二醛交联壳聚糖液滴，得到纳米粒子包覆的微球。SEM 表征表明，微球单分散且表面纳米粒子分布均匀。通过改变微流控流动参数，很容易控制微球的分散性、尺寸和组成，并且成功地使用了三种不同类型的纳米粒子来合成杂化微球，以证明该方法的多功能性。
