• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

I类和II类主要组织相容性复合体（MHC）限制的细胞毒性T细胞介导的细胞溶解中蛋白质合成的差异需求

Differential requirement for protein synthesis in cytolysis mediated by class I and class II MHC-restricted cytotoxic T cells.

作者信息

Tite J P

机构信息

Department of Molecular Biology, Wellcome Biotech, Beckenham, Kent, U.K.

出版信息

Immunology. 1990 Aug;70(4):440-5.

PMID:2118476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384246/
Abstract

Antigen-specific cytolysis by major histocompatibility complex (MHC) class II-restricted cloned T-cell lines was found to be dependent on protein synthesis. Cytolysis by both polyclonal short-term and long-term class I-restricted cytotoxic T lymphocytes (CTL) was almost completely insensitive to inhibitors of protein synthesis. Kinetic studies with class II-restricted CTL indicated that approximately 2-3 hr after initiation of activation, resistance to inhibitors of protein synthesis was acquired. This strongly suggests that either a cytotoxic effector molecule or an intermediary important in the delivery of such a molecule is synthesized rapidly after activation in class II-restricted CTL, whilst class I-restricted CTL have no such requirement.

摘要

研究发现，主要组织相容性复合体（MHC）Ⅱ类分子限制性克隆T细胞系的抗原特异性细胞溶解作用依赖于蛋白质合成。多克隆短期和长期Ⅰ类分子限制性细胞毒性T淋巴细胞（CTL）的细胞溶解作用对蛋白质合成抑制剂几乎完全不敏感。对Ⅱ类分子限制性CTL的动力学研究表明，激活开始后约2 - 3小时，细胞获得了对蛋白质合成抑制剂的抗性。这有力地表明，在Ⅱ类分子限制性CTL激活后会迅速合成一种细胞毒性效应分子或在传递此类分子中起重要作用的中间体，而Ⅰ类分子限制性CTL则无此需求。

相似文献

1
Differential requirement for protein synthesis in cytolysis mediated by class I and class II MHC-restricted cytotoxic T cells.I类和II类主要组织相容性复合体（MHC）限制的细胞毒性T细胞介导的细胞溶解中蛋白质合成的差异需求
Immunology. 1990 Aug;70(4):440-5.
2
Evidence of a role for TNF-alpha in cytolysis by CD4+, class II MHC-restricted cytotoxic T cells.肿瘤坏死因子-α在CD4⁺、Ⅱ类主要组织相容性复合体限制的细胞毒性T细胞介导的细胞溶解中作用的证据。
Immunology. 1990 Oct;71(2):208-12.
3
T lymphocyte responses to multiple minor histocompatibility antigens generate both self-major histocompatibility complex-restricted and cross-reactive cytotoxic T lymphocytes.T淋巴细胞对多种次要组织相容性抗原的反应会产生自身主要组织相容性复合体限制的和交叉反应性细胞毒性T淋巴细胞。
Transplantation. 1994 Jul 15;58(1):59-67.
4
Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells.小鼠L3T4 + T细胞中II类主要组织相容性复合体限制的细胞溶解与淋巴因子分泌之间关系的克隆分析。
Immunology. 1991 Feb;72(2):256-60.
5
T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.引发同种特异性细胞毒性T淋巴细胞反应的T细胞-辅助细胞相互作用：Ia限制型和Ia非限制型细胞相互作用途径的存在。
J Immunol. 1984 May;132(5):2199-209.
6
The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens.T8在针对II类和I类主要组织相容性复合体抗原的克隆化细胞毒性T淋巴细胞系的细胞毒性活性中的作用。
J Immunol. 1985 Apr;134(4):2294-8.
7
Class II antigen-specific murine cytolytic T lymphocytes (CTL). II. Genuine class II specificity of Lyt-2+ CTL clones.II类抗原特异性小鼠细胞毒性T淋巴细胞（CTL）。II. Lyt-2+ CTL克隆的真正II类特异性。
J Immunol. 1988 Jan 1;140(1):30-6.
8
Anti-tumor activity of class II MHC antigen-restricted cloned autoreactive T cells. I. Destruction of B16 melanoma cells mediated by bystander cytolysis in vitro.II类主要组织相容性复合体抗原限制的克隆自身反应性T细胞的抗肿瘤活性。I. 体外旁观者细胞溶解介导的B16黑色素瘤细胞破坏。
J Immunol. 1987 Mar 15;138(6):1971-8.
9
Requirement for recognition of class II molecules and processed tumor antigen for optimal generation of syngeneic tumor-specific class I-restricted CTL.为了最佳地产生同基因肿瘤特异性I类限制性细胞毒性T淋巴细胞（CTL），对II类分子和加工后的肿瘤抗原识别的要求。
J Immunol. 1986 Jun 1;136(11):4303-10.
10
Major histocompatibility complex class II-restricted cytotoxicity by self-myelin basic protein-reactive T-cell hybridomas: evidence for a tumour necrosis factor-independent nucleolytic mechanism.主要组织相容性复合体II类限制性自身髓鞘碱性蛋白反应性T细胞杂交瘤的细胞毒性：肿瘤坏死因子非依赖性核酸溶解机制的证据。
Immunology. 1993 Feb;78(2):273-8.

引用本文的文献

1
In vivo lymphokine production in experimental autoimmune uveoretinitis.实验性自身免疫性葡萄膜视网膜炎中的体内淋巴因子产生
Immunology. 1993 Mar;78(3):387-92.
2
Major histocompatibility complex class II-restricted cytotoxicity by self-myelin basic protein-reactive T-cell hybridomas: evidence for a tumour necrosis factor-independent nucleolytic mechanism.主要组织相容性复合体II类限制性自身髓鞘碱性蛋白反应性T细胞杂交瘤的细胞毒性：肿瘤坏死因子非依赖性核酸溶解机制的证据。
Immunology. 1993 Feb;78(2):273-8.
3
Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.靶标Fas蛋白参与CD4 + Th1和CD8 + 细胞毒性T细胞诱导的凋亡途径。
Proc Natl Acad Sci U S A. 1994 May 10;91(10):4185-9. doi: 10.1073/pnas.91.10.4185.
4
Evidence of a role for TNF-alpha in cytolysis by CD4+, class II MHC-restricted cytotoxic T cells.肿瘤坏死因子-α在CD4⁺、Ⅱ类主要组织相容性复合体限制的细胞毒性T细胞介导的细胞溶解中作用的证据。
Immunology. 1990 Oct;71(2):208-12.
5
Clonal analysis of the relationship between class II MHC-restricted cytolysis and lymphokine secretion in murine L3T4+ T cells.小鼠L3T4 + T细胞中II类主要组织相容性复合体限制的细胞溶解与淋巴因子分泌之间关系的克隆分析。
Immunology. 1991 Feb;72(2):256-60.
6
Inhibition of T-cell mediated cytotoxicity by Novobiocin suggests multiple pathways for both CD4+ and CD8+ cytotoxic T cells.新生霉素对T细胞介导的细胞毒性的抑制作用表明，CD4+和CD8+细胞毒性T细胞存在多种作用途径。
Immunology. 1992 Jul;76(3):460-4.

本文引用的文献

1
The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells.长期同种特异性T细胞系的Lyt表型。对IA的辅助和杀伤活性均由Ly-1细胞介导。
Eur J Immunol. 1981 Mar;11(3):175-80. doi: 10.1002/eji.1830110304.
2
Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization.细胞溶解性T细胞颗粒。分离、结构、生化及功能特性
J Exp Med. 1984 Sep 1;160(3):695-710. doi: 10.1084/jem.160.3.695.
3
Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis.克隆化辅助性T细胞在存在特异性抗原的情况下可杀伤B淋巴瘤细胞：细胞溶解中的Ia限制以及同源与非同源相互作用
Eur J Immunol. 1984 Oct;14(10):878-86. doi: 10.1002/eji.1830141004.
4
The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells.甲型流感病毒核蛋白基因控制亚型特异性和交叉反应性细胞毒性T细胞的诱导。
J Exp Med. 1984 Aug 1;160(2):552-63. doi: 10.1084/jem.160.2.552.
5
The polypeptide composition of influenza A viruses.甲型流感病毒的多肽组成。
Virology. 1971 May;44(2):396-408. doi: 10.1016/0042-6822(71)90270-4.
6
An effector-cell independent step in target cell lysis by sensitized mouse lymphocytes.致敏小鼠淋巴细胞在靶细胞裂解过程中的效应细胞非依赖步骤。
J Immunol. 1973 Nov;111(5):1538-45.
7
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.在同基因或半同种异体系统中淋巴细胞性脉络丛脑膜炎体外T细胞介导的细胞毒性的限制。
Nature. 1974 Apr 19;248(5450):701-2. doi: 10.1038/248701a0.
8
A novel serine esterase expressed by cytotoxic T lymphocytes.一种由细胞毒性T淋巴细胞表达的新型丝氨酸酯酶。
Nature. 1985;314(6013):743-5. doi: 10.1038/314743a0.
9
Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell.
Proc Natl Acad Sci U S A. 1985 Jan;82(1):183-7. doi: 10.1073/pnas.82.1.183.
10
A family of serine esterases in lytic granules of cytolytic T lymphocytes.细胞毒性T淋巴细胞溶细胞颗粒中的丝氨酸酯酶家族。
Cell. 1987 Jun 5;49(5):679-85. doi: 10.1016/0092-8674(87)90544-7.