Instituto de Biomedicina de Sevilla, Hospitales Universitarios Virgen del Rocío/CSIC/Universidad de Sevilla, Clinical and Molecular Epidemiology Seville, Spain.
J Adolesc Health. 2011 Jan;48(1):103-5. doi: 10.1016/j.jadohealth.2010.05.013. Epub 2010 Aug 24.
Pneumocystis colonization in young HIV-infected patients has been poorly studied. The aim of this study was to analyze the prevalence of P jiroveci colonization in a cohort of young HIV-infected patients.
We designed a basal cross-sectional study in 20 young HIV-infected patients to determine the prevalence of P jiroveci colonization in oropharyngeal wash samples studied by nested polymerase chain reaction (PCR). Subsequently, patients were followed up during 50 weeks to observe the development of Pneumocystis pneumonia (PCP).
P jiroveci colonization was detected in eight (40%) of the 20 oropharyngeal wash samples. Genotype 85C/248C was the most frequent. After 50 weeks of follow-up, one colonized patient with advanced immunodepression developed PCP.
We have found a high prevalence of P jiroveci colonization in young HIV-infected patients with a major prevalence of genotype 1 (85C/248C). Further studies are necessary to clarify if Pneumocystis colonization could be a potential risk factor of developing PCP in young HIV infected patients.
肺部卡氏肺囊虫定植在年轻的 HIV 感染者中研究较少。本研究旨在分析年轻 HIV 感染者队列中肺部卡氏肺囊虫定植的流行率。
我们设计了一项基础的 20 例年轻 HIV 感染者的横断面研究，以通过巢式聚合酶链反应（PCR）确定在口腔冲洗样本中肺部卡氏肺囊虫定植的流行率。随后，对患者进行了 50 周的随访，以观察是否发生卡氏肺囊虫肺炎（PCP）。
在 20 例口腔冲洗样本中，有 8 例（40%）检测到肺部卡氏肺囊虫定植。最常见的基因型是 85C/248C。在 50 周的随访后，1 例免疫功能严重受损的定植患者发生了 PCP。
我们发现年轻 HIV 感染者中肺部卡氏肺囊虫定植率较高，主要基因型为 1（85C/248C）。需要进一步研究以明确肺部卡氏肺囊虫定植是否可能成为年轻 HIV 感染者发生 PCP 的潜在危险因素。
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