巴西南部艾滋病毒阳性患者中耶氏肺孢子菌定植的高流行率。

High prevalence of Pneumocystis jirovecii colonization among HIV-positive patients in southern Brazil.

作者信息

Pereira Robson M, Müller André L, Zimerman Ricardo A, Antunes Denise B, Zinn Vitor F, Friaza Vicente, de la Horra Carmen, Calderón Enrique J, Wissmann Gustavo

机构信息

Pneumocystis Study Group, Infectious Diseases Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Federal University of Rio Grande do Sul, Brazil.

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública and Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain.

出版信息

Med Mycol. 2014 Nov;52(8):804-9. doi: 10.1093/mmy/myu059. Epub 2014 Oct 6.

DOI:10.1093/mmy/myu059

PMID:25288653

Abstract

A high prevalence of Pneumocystis jirovecii colonization was observed in patients positive for the human immunodeficiency virus (HIV) admitted to a tertiary hospital in southern Brazil between August 2012 and December 2012. Amplification of the mitochondrial large subunit ribosomal RNA gene in oropharyngeal samples through nested polymerase chain reaction identified P. jirovecii colonization in 26 of 58 (44.8%) HIV-positive patients admitted for causes other than Pneumocystis pneumonia. Colonization was more frequent among patients with an absolute CD4 count ≤200 cells/μl. These findings suggest that the HIV-infected population is a major reservoir and source of P. jirovecii infection and that identification of such individuals may contribute to future strategies for improving management of HIV-infected patients.

摘要

2012年8月至2012年12月期间，在巴西南部一家三级医院收治的人类免疫缺陷病毒（HIV）阳性患者中，观察到耶氏肺孢子菌定植的高流行率。通过巢式聚合酶链反应扩增口咽样本中的线粒体大亚基核糖体RNA基因，在58例因非肺孢子菌肺炎原因入院的HIV阳性患者中，有26例（44.8%）检测到耶氏肺孢子菌定植。在绝对CD4细胞计数≤200个/μl的患者中，定植更为常见。这些发现表明，HIV感染人群是耶氏肺孢子菌感染的主要储存库和来源，识别这类个体可能有助于未来改善HIV感染患者管理的策略。