Naranjo Antonio, Ojeda-Bruno Soledad, Francisco-Hernández Félix, Erausquin Celia, Rúa-Figueroa Iñigo, Rodríguez-Lozano Carlos
Servicio de Reumatología, Hospital Universitario de Gran Canaria Dr. Negrín,. Universidad de Las Palmas de Gran Canaria, España.
Med Clin (Barc). 2011 Mar 19;136(7):290-2. doi: 10.1016/j.medcli.2010.06.028. Epub 2010 Dec 24.
There are different guidelines for secondary prevention of fractures related with osteoporosis. Our aim is to analyse the appliance of such guidelines in a sample of patients with fragility fracture
Adult patients older than 50 years attended in the emergency department with a fragility fracture were invited to participate in a study for secondary prevention. Clinical data and densitometry for the FRAX index were recorded. Current guidelines were employed to calculate the number of patients who needed secondary prevention.
With the appliance of current guidelines to 380 patients, 54-100% of women and 26-81% of men were candidates for treatment. For hip fractures the percentage was 81-100% and for forearm fractures 36-93%. FRAX index for hip fracture was ≥3% in 35% of patients. The National Institute for Health and Clinical Excellence and the National Osteoporosis Foundation 2009 were the most restrictive guidelines (54% and 57% respectively). On the other hand the National Guideline Clearinghouse (87%) and the National Osteoporosis Guideline Group (93%).
There are high differences in the percentage of patients who need treatment to prevent new fractures according to the guidelines. Fewer patients require treatment when the FRAX index is included in a guideline.
对于与骨质疏松症相关的骨折二级预防,存在不同的指南。我们的目的是分析此类指南在一组脆性骨折患者中的应用情况。
邀请年龄大于50岁、因脆性骨折到急诊科就诊的成年患者参与一项二级预防研究。记录临床数据及FRAX指数的骨密度测量值。采用现行指南计算需要二级预防的患者数量。
将现行指南应用于380例患者时,54% - 100%的女性和26% - 81%的男性为治疗候选对象。髋部骨折患者的比例为81% - 100%,前臂骨折患者的比例为36% - 93%。35%的患者髋部骨折的FRAX指数≥3%。英国国家卫生与临床优化研究所(National Institute for Health and Clinical Excellence)及2009年美国国家骨质疏松基金会(National Osteoporosis Foundation)的指南限制最为严格(分别为54%和57%)。另一方面,美国国家指南交换中心(National Guideline Clearinghouse)(87%)和英国国家骨质疏松指南小组(National Osteoporosis Guideline Group)(93%)的指南限制相对宽松。
根据不同指南,需要接受治疗以预防新发骨折的患者比例存在很大差异。当指南纳入FRAX指数时,需要治疗的患者较少。