McDermott M T, Sjoberg R J, Hofeldt F D, Kidd G S
Department of Medicine, Fitzsimons Army Medical Center, Aurora, CO 80045-5001.
J Lab Clin Med. 1990 Aug;116(2):187-90.
We examined the effects of elevated thyrotropin-releasing hormone (TRH) levels on the gonadotropin response to gonadotropin-releasing hormone (GnRH) in 16 healthy men. A TRH infusion, which was begun 15 minutes before and continued for 120 minutes after the bolus administration of GnRH, was compared with a saline infusion. During the TRH infusion the gonadotropin responses to acute GnRH stimulation were higher than in the saline control period but, although statistically significant, the differences were small in magnitude and were similar to the intraindividual coefficient of variation in gonadotropin responses determined under control conditions. They did not appear to be of clinical significance. TRH significantly lengthened the interval between GnRH administration and the appearance of peak gonadotropin levels. These results indicate that a brief TRH infusion, producing mild elevations of thyrotropin and prolactin, causes slight alterations predominantly in the timing of GnRH-stimulated gonadotropin secretion.
我们研究了16名健康男性中促甲状腺激素释放激素（TRH）水平升高对促性腺激素释放激素（GnRH）刺激下促性腺激素反应的影响。将在GnRH推注前15分钟开始并在推注后持续120分钟的TRH输注与生理盐水输注进行比较。在TRH输注期间，促性腺激素对急性GnRH刺激的反应高于生理盐水对照期，尽管差异具有统计学意义，但幅度较小，且与在对照条件下测定的促性腺激素反应的个体内变异系数相似。它们似乎没有临床意义。TRH显著延长了GnRH给药与促性腺激素峰值水平出现之间的间隔。这些结果表明，短暂的TRH输注导致促甲状腺激素和催乳素轻度升高，主要引起GnRH刺激的促性腺激素分泌时间的轻微改变。
