Carol W, Lauterbach H, Klinger G
Zentralbl Gynakol. 1984;106(6):359-67.
Intravenous administration of gonadotropin-releasing hormone (GnRH) induces not only a rapid release of pituitary LH and FSH stored, but also stimulates biosynthesis of these hormones by a long acting process. Repeated injection of GnRH after an interval of 90 to 120 minutes evokes an increased response compared with the first period of stimulation. This pattern of reaction is principally maintained on therapy with steroidal contraceptives. The twofold stimulation provides additional information on hypothalamic-pituitary reactivity exceeding the results yielded by the simple GnRH stimulation test. On the contrary examination of prolactin response to twofold TRH-administration gives no increased diagnostic aid.
静脉注射促性腺激素释放激素（GnRH）不仅能促使垂体中储存的促黄体生成素（LH）和促卵泡生成素（FSH）迅速释放，还能通过一个长效过程刺激这些激素的生物合成。在间隔90至120分钟后重复注射GnRH，与首次刺激期相比，会引发增强的反应。这种反应模式在使用甾体避孕药治疗时基本保持。这种双重刺激提供了关于下丘脑 - 垂体反应性的额外信息，超过了简单GnRH刺激试验所产生的结果。相反，对催乳素对双重促甲状腺激素释放激素（TRH）给药的反应进行检查，并未提供更多的诊断帮助。
