Milgram N W, Racine R J, Nellis P, Mendonca A, Ivy G O
Department of Psychology, University of Toronto, Ont., Canada.
Life Sci. 1990;47(5):415-20. doi: 10.1016/0024-3205(90)90299-7.
The effect of l-deprenyl on longevity was examined in male Fischer rats. Subcutaneous injections of either l-deprenyl (0.25 mg/kg) or saline were given every other day starting at 23 to 25 months of age. The deprenyl-treated animals showed a significant increase in both mean and maximum survival. The differences were largest in the longest surviving animals, suggesting that an earlier onset for treatment may be beneficial. Analysis of body weights ruled out deprenyl-induced dietary restriction as an explanation for the group differences in survival. To the contrary, after about four months of treatment, the animals of l-deprenyl showed a slower rate of decrease in body weight than the controls.
在雄性费希尔大鼠中研究了左旋司来吉兰对寿命的影响。从23至25月龄开始，每隔一天皮下注射左旋司来吉兰（0.25毫克/千克）或生理盐水。接受司来吉兰治疗的动物在平均生存期和最长生存期均显著增加。差异在存活时间最长的动物中最为明显，这表明更早开始治疗可能有益。对体重的分析排除了司来吉兰诱导的饮食限制作为组间生存差异的解释。相反，在治疗约四个月后，左旋司来吉兰治疗组动物体重下降速度比对照组慢。
