Kitani K, Kanai S, Sato Y, Ohta M, Ivy G O, Carrillo M C
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Life Sci. 1993;52(3):281-8. doi: 10.1016/0024-3205(93)90219-s.
Seventy male Fischer 344 (F-344) rats were treated with s.c. injection of (-)deprenyl (0.5 mg/kg, n = 35) or physiological saline (n = 35) 3 times a week from the age of 18 months until the time of their natural death. The fifty percent survival time was 28 months in control animals and 30 months in the deprenyl treated group. The mean survival time after the start of treatment (18 months) and after 24 months were 378.3 +/- 97.4 days (mean +/- SD) and 196.3 +/- 97.4 days, respectively, in deprenyl treated rats and 328.7 +/- 108.8 days and 146.7 +/- 108.7 days in control rats. The increases in average life expectancies caused by deprenyl treatment (15% from 18 months and 34% from 24 months) were both statistically significant (P < 0.05, two-tailed t-test). The average body weights were comparable for both groups but the variation of body weight was greater in control groups, thus excluding the possibility that the life prolonging effect of deprenyl results from reduced dietary intake. The results confirm those of two previous studies (1,2) which reported a significant life prolonging effect of deprenyl in aged rats and lend added support to the results of a study on male F-344 rats where the effect was only marginally significant (16% increase after 24 months, P = 0.048 by one-tailed t test) (2).
70只雄性Fischer 344（F - 344）大鼠，从18月龄开始，每周皮下注射（-）司来吉兰（0.5mg/kg，n = 35）或生理盐水（n = 35）3次，直至自然死亡。对照组动物的半数存活时间为28个月，司来吉兰治疗组为30个月。在司来吉兰治疗的大鼠中，治疗开始后（18个月）和24个月后的平均存活时间分别为378.3±97.4天（平均值±标准差）和196.3±97.4天，对照组大鼠分别为328.7±108.8天和146.7±108.7天。司来吉兰治疗导致的平均预期寿命增加（18个月时增加15%，24个月时增加34%）均具有统计学意义（P < 0.05，双侧t检验）。两组的平均体重相当，但对照组的体重变化更大，因此排除了司来吉兰延长寿命的效果是由于饮食摄入量减少所致的可能性。这些结果证实了之前两项研究（1,2）的结果，这两项研究报告了司来吉兰对老年大鼠有显著的寿命延长作用，并进一步支持了一项关于雄性F - 344大鼠的研究结果，该研究中该作用仅略微显著（24个月后增加16%，单尾t检验P = 0.048）（2）。
