Ozgen Metin, Koca Suleyman Serdar, Dagli Necati, Balin Mehmet, Ustundag Bilal, Isik Ahmet
Department of Rheumatology, Firat University, Elazig, Turkey.
Regul Pept. 2011 Feb 25;167(1):125-8. doi: 10.1016/j.regpep.2010.12.003. Epub 2010 Dec 24.
Rheumatoid arthritis (RA), a chronic inflammatory disease, leads to early and accelerated atherosclerosis; however, its pathogenesis is not yet fully documented. Salusin-α and β are novel bioactive peptides. Salusin-α suppresses macrophage foam cell formation, while salusin-β stimulates. Moreover, decreased serum salusin-α level has been reported previously in patients with coronary artery disease. The aims of the study were to assess serum salusin-α level and its association with predictors of atherosclerosis in a cohort of patients with RA. The study included 56 RA patients, 37 Behcet's disease (BD) patients, and 29 healthy controls (HC). TNF-α, IL-6 and salusin-α levels, homeostasis model assessment (HOMA-IR) index and common carotid intima-media thickness (IMT) were determined. In the RA and BD groups, salusin-α levels (p<0.001 and p<0.01, respectively) and IMTs (p<0.001 for both) were higher compared to the HC group. However, the level of salusin-α was not directly associated with the IMT in all the groups. Serum salusin-α levels are increased in RA and BD, although they have increased IMT. Salusin-α has been reported to have anti-atherogenic effects in previous studies. However, it seems that salusin-α does not directly affect the atherogenesis in RA and BD. Further studies are needed to understand the regulation of salusin-α and determination of its relations with the predictors of atherosclerosis in RA and BD.
类风湿性关节炎（RA）是一种慢性炎症性疾病，会导致早期和加速动脉粥样硬化；然而，其发病机制尚未完全明确。Salusin-α和β是新型生物活性肽。Salusin-α可抑制巨噬细胞泡沫细胞形成，而Salusin-β则起刺激作用。此外，先前有报道称冠心病患者血清Salusin-α水平降低。本研究的目的是评估一组类风湿性关节炎患者的血清Salusin-α水平及其与动脉粥样硬化预测指标的关联。该研究纳入了56例类风湿性关节炎患者、37例白塞病（BD）患者和29例健康对照者（HC）。测定了肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和Salusin-α水平、稳态模型评估（HOMA-IR）指数以及颈总动脉内膜中层厚度（IMT）。与健康对照组相比，类风湿性关节炎组和白塞病组的Salusin-α水平（分别为p<0.001和p<0.01）以及IMT（两组均为p<0.001）更高。然而，在所有组中，Salusin-α水平与IMT并无直接关联。类风湿性关节炎组和白塞病组的血清Salusin-α水平升高，尽管其IMT也有所增加。先前的研究报道Salusin-α具有抗动脉粥样硬化作用。然而，Salusin-α似乎并未直接影响类风湿性关节炎和白塞病的动脉粥样硬化形成过程。需要进一步研究以了解Salusin-α的调节机制及其与类风湿性关节炎和白塞病动脉粥样硬化预测指标之间的关系。
