Wang Peng, Guan Shi-Yang, Xu Shu-Zhen, Li Hong-Miao, Leng Rui-Xue, Li Xiang-Pei, Pan Hai-Feng
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Anhui provincial laboratory of population health and major disease screening and diagnosis, Anhui, 230032, People's Republic of China.
Clin Rheumatol. 2016 Feb;35(2):315-23. doi: 10.1007/s10067-015-3130-8. Epub 2015 Nov 27.
This study aims to derive a more precise estimation on carotid intima-media thickness (CIMT) level in patients with rheumatoid arthritis (RA) and related factors. Studies published from January 1, 1982 to December 31, 2014 in English, which comparing CIMT between RA group and control group were searched in PubMed, Embase, and Cochrane Library databases. Heterogeneity test was performed, and publication bias was evaluated. Stata software 12.0 was used to perform the meta-analysis. Two-thousand one hundred sixty-three articles were obtained after searching databases, and 47 studies were finally included in the meta-analysis. The result of the analysis in random effect model showed that RA group had significantly higher CIMT than control group, with the standardized mean difference (SMD) of 1.04 and 95% CI (0.81,1.27). To evaluate the stability of our results, sensitivity analyses were performed, and the results showed no significant change when any one study was excluded. Subgroup analyses showed that region, race, age, BMI, and disease duration were associated with CIMT in RA patients. In summary, CIMT in RA patients is thicker than healthy controls, and it is influenced by region, race, age, BMI, and disease duration.
本研究旨在更精确地评估类风湿关节炎（RA）患者的颈动脉内膜中层厚度（CIMT）水平及其相关因素。在PubMed、Embase和Cochrane图书馆数据库中检索了1982年1月1日至2014年12月31日期间发表的英文研究，这些研究比较了RA组和对照组之间的CIMT。进行了异质性检验，并评估了发表偏倚。使用Stata软件12.0进行荟萃分析。检索数据库后获得2163篇文章，最终47项研究纳入荟萃分析。随机效应模型分析结果显示，RA组的CIMT显著高于对照组，标准化平均差（SMD）为1.04，95%置信区间（CI）为（0.81,1.27）。为评估结果的稳定性，进行了敏感性分析，结果显示排除任何一项研究时结果无显著变化。亚组分析表明，地区、种族、年龄、体重指数（BMI）和病程与RA患者的CIMT相关。总之，RA患者的CIMT比健康对照者厚，且受地区、种族、年龄、BMI和病程影响。
