中国猫传染性贫血病毒（TTV）的分子检测与序列分析。
Molecular detection and sequence analysis of feline Torque teno virus (TTV) in China.
机构信息
Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai JiaoTong University, Shanghai 200240, China.
出版信息
Virus Res. 2011 Mar;156(1-2):13-6. doi: 10.1016/j.virusres.2010.12.008. Epub 2010 Dec 24.
In the present study, two isolates (SH-F1 and SH-F2) of Torque teno felis virus (feline TTV) were detected in 16 (12.5%) serum samples collected from cats in China. Their full length genomes were cloned and sequenced. The results showed that they were 2063bp in length and contained three open reading frames (ORFs) (ORF1: nt438-1748, ORF2: nt268-585 and ORF3: nt268-581, 1461-1842). Phylogenetic analysis showed that they were clustered with the strain of Japan (Fc-TTV4, AB076003) and the strain of France (PRA4, EF538878). Sequence analysis indicated that SH-F1 had high (97.5% and 93.3%) identity with the strain of Japan and the strain of France, and SH-F2 shared 94.5% and 92.1% homology with them, respectively. In conclusion, we demonstrated that feline TTV is present in China.
在本研究中，从中国的猫血清样本中检测到了两株（SH-F1 和 SH-F2）弓首蛔虫病毒（猫 TTV）。它们的全长基因组被克隆并测序。结果表明，它们的长度为 2063bp，包含三个开放阅读框（ORF）（ORF1：nt438-1748，ORF2：nt268-585 和 ORF3：nt268-581，1461-1842）。系统进化分析表明，它们与日本株（Fc-TTV4，AB076003）和法国株（PRA4，EF538878）聚类在一起。序列分析表明，SH-F1 与日本株和法国株的同源性分别高达 97.5%和 93.3%，而 SH-F2 与它们的同源性分别为 94.5%和 92.1%。总之，我们证明了猫 TTV 在中国存在。
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