BioMag Laboratory, Helsinki University Central Hospital, Finland.
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):550-3. doi: 10.1016/j.pnpbp.2010.12.015. Epub 2010 Dec 23.
Alcohol withdrawal syndrome (AWS) develops after cessation of alcohol intake in alcoholic patients characterizing psychiatric symptoms and changes in autonomous nervous systems. We studied cardiovascular changes during different phases of AWS (1, 2, 3 and 10 days after admission for detoxification; n=34) and compared them with those in early recovery (at least 1 month of abstinence; n=30). The results study showed that cardiovascular system underwent significant changes during AWS characterizing the decrease of heart rate, systolic and diastolic blood pressures, and total peripheral resistance. Stroke index was lower during AWS than in early recovery. As the decreased stroke index was compensated by increased heart rate, cardiac index did not differ during AWS from that in early recovery. Increased functioning of noradrenaline (along with other central and peripheral regulating mechanisms) may be an important factor associated with cardiovascular changes in AWS. Normalization of this function after AWS leads to returning of cardiovascular parameters to baseline levels.
酒精戒断综合征（AWS）发生在酗酒患者停止饮酒后，以精神症状和自主神经系统变化为特征。我们研究了 AWS 的不同阶段（入院解毒后 1、2、3 和 10 天；n=34）期间的心血管变化，并将其与早期恢复期（至少 1 个月的禁欲；n=30）进行了比较。研究结果表明，AWS 期间心血管系统发生了显著变化，表现为心率、收缩压和舒张压以及总外周阻力降低。AWS 期间的 stroke index 低于早期恢复期。由于 stroke index 的降低被心率的增加所代偿，AWS 期间的心输出量与早期恢复期没有差异。去甲肾上腺素（以及其他中枢和外周调节机制）的功能增加可能是与 AWS 心血管变化相关的一个重要因素。AWS 后这种功能的正常化导致心血管参数恢复到基线水平。
