Department of Organic Chemistry, Institute of Biotechnology, University of Granada, Avda Fuente Nueva, s/n, 18071 Granada, Spain.
Org Biomol Chem. 2011 Feb 21;9(4):1118-25. doi: 10.1039/c0ob00467g. Epub 2010 Dec 24.
Highly efficient preparations of anticancer β-elemene and other bioactive elemanes were carried out using the natural product germacrone as a renewable starting material. The syntheses were achieved in only 3-5 steps with excellent overall yields (43-54%). An enantioselective approach to these molecules is also described.
使用天然产物吉马酮作为可再生起始原料，高效制备抗癌β-榄香烯和其他生物活性榄香醇。这些合成仅需 3-5 步，总收率优异（43-54%）。还描述了这些分子的对映选择性方法。
