Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Building I, Room 1404E, Boston, MA 02115, USA.
Pediatrics. 2011 Jan;127(1):e59-68. doi: 10.1542/peds.2009-3556. Epub 2010 Dec 27.
We evaluated the associations of serum dioxins and polychlorinated biphenyls (PCBs) with longitudinally assessed growth measurements among peripubertal Russian boys.
A total of 499 boys from Chapaevsk, Russia, aged 8 to 9 years were enrolled in the study from 2003 to 2005 and were followed prospectively for 3 years. Blood samples were collected and physical examinations were conducted at entry and repeated at annual study visits. Multivariate mixed-effects regression models for repeated measures were used to examine the associations of serum dioxins and PCBs with longitudinal measurements of BMI, height, and height velocity.
Serum dioxin (total 2005 toxic equivalency [TEQ] median: 21.1 pg/g lipid) and PCBs (median sum of PCBs: 250 ng/g lipid) were measured in 468 boys. At study entry and during 3 years of follow-up, >50% of the boys had age-adjusted BMI and height z scores within 1 SD of World Health Organization-standardized mean values for age. Boys in the highest exposure quintile of the sum of dioxin and PCB concentrations and total TEQs had a significant decrease in mean BMI z scores of 0.67 for dioxins and TEQs and 1.04 for PCBs, compared with boys in the lowest exposure quintile. Comparison of the highest versus the lowest quintile revealed that higher serum PCB concentrations were associated with significantly lower height z scores (mean z-score decrease: 0.41) and height velocity (mean decrease: 0.19 cm/year) after 3 years of follow-up.
Our findings suggest that exposures to dioxins and PCBs are associated with reduced growth during the peripubertal period and may compromise adult body mass, stature, and health.
我们评估了血清二恶英和多氯联苯（PCBs）与俄罗斯青春期前男孩纵向生长测量值的相关性。
2003 年至 2005 年，我们在俄罗斯恰帕耶夫斯克招募了 499 名 8 至 9 岁的男孩，对他们进行了前瞻性随访 3 年。在入组时和每年的研究访视时采集血样并进行体格检查。我们使用多变量混合效应重复测量模型来检验血清二恶英和 PCBs 与 BMI、身高和身高速度的纵向测量值之间的关联。
我们在 468 名男孩中测量了血清二恶英（2005 年总毒性等效物 [TEQ] 中位数：21.1 pg/g 脂质）和 PCBs（PCBs 总和中位数：250 ng/g 脂质）。在研究入组时和 3 年随访期间，超过 50%的男孩的年龄调整 BMI 和身高 z 分数在世界卫生组织年龄标准化平均值的 1 SD 范围内。与最低浓度五分位数的男孩相比，浓度总和五分位数最高的二恶英和 PCB 浓度以及总 TEQ 的男孩的平均 BMI z 分数分别下降了 0.67 和 1.04，最高浓度五分位数的男孩的平均 BMI z 分数分别下降了 0.67 和 1.04。与最低浓度五分位数相比，最高浓度五分位数与身高 z 分数（平均身高 z 分数下降：0.41）和身高速度（平均下降：0.19 cm/年）明显较低相关。
我们的研究结果表明，二恶英和 PCBs 的暴露与青春期期间的生长减少有关，可能会影响成年后的体重、身高和健康。
