Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
Environmental Toxicology, Flemish Institute of Technological Research, Mol, Belgium.
Environ Int. 2010 May;36(4):330-337. doi: 10.1016/j.envint.2010.01.005. Epub 2010 Feb 24.
Flanders is densely populated with much industry and intensive farming. Body size of 14- to 15-year old adolescents and of adults aged 50-65 was studied in relation to internal exposure to pollutants. 1679 adolescents (887 boys and 792 girls), 775 men and 808 women were selected as a random sample of the population. Concentrations of pollutants in blood or urine were measured in accordance with quality control/quality assurance procedures. Self-assessment questionnaires provided information on personal and life-style factors. Height and weight of subjects were measured. Confounding factors and significant covariates were taken into account. For boys and girls, height and body mass index (BMI) showed a negative association with urinary concentration of cadmium and BMI also with serum concentration of hexachlorobenzene (HCB) and with the sum of serum concentrations of polychlorinated biphenyls (PCBs) 138, 153, and 180 (marker PCBs), whereas BMI showed a positive association with serum concentration of PCB 118. For boys, height showed a negative association with urinary concentration of 1-hydroxypyrene (1-OHP) and positive associations with serum concentrations of HCB and PCB 118. For adults no significant associations between internal exposure and height were observed. For men, BMI showed negative associations with urinary cadmium concentration and with serum levels of marker PCBs and positive associations with serum levels of HCB, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), PCB 118 and the dioxin fraction of dioxin-like activity. For women, BMI showed a negative association with urinary cadmium concentration, with blood lead concentration and with the concentration of marker PCBs in serum, and a positive association with serum concentrations of HCB, p,p'-DDE and PCB 118. Associations between biological effects and internal exposures were, in terms of the regression coefficient, often stronger at exposures below the median. Environmental exposures to pollutants resulting in "normal" levels of internal exposure were associated with quite substantial differences in body mass index.
佛兰德斯人口密集，工业和集约化农业发达。为了研究体内污染物暴露与 14 至 15 岁青少年和 50 至 65 岁成年人身体大小的关系，从人群中抽取了 1679 名青少年（887 名男性和 792 名女性）、775 名男性和 808 名女性作为随机样本。根据质量控制/质量保证程序测量了血液或尿液中污染物的浓度。通过自我评估问卷提供了个人和生活方式因素的信息。测量了研究对象的身高和体重。考虑了混杂因素和重要的协变量。对于男孩和女孩，身高和体重指数（BMI）与尿镉浓度呈负相关，BMI 也与血清六氯苯（HCB）浓度以及多氯联苯（PCBs）138、153 和 180 血清浓度总和（标记 PCBs）呈负相关，而 BMI 与血清 PCB118 浓度呈正相关。对于男孩，身高与尿 1-羟苊（1-OHP）浓度呈负相关，与 HCB 和 PCB118 血清浓度呈正相关。对于成年人，体内暴露与身高之间未观察到显著相关性。对于男性，BMI 与尿镉浓度呈负相关，与标记 PCBs 血清水平呈正相关，与 HCB、p,p'-二氯二苯二氯乙烯（p,p'-DDE）、PCB118 和二恶英样活性的二恶英部分血清水平呈正相关。对于女性，BMI 与尿镉浓度、血铅浓度和血清中标记 PCBs 浓度呈负相关，与 HCB、p,p'-DDE 和 PCB118 血清浓度呈正相关。在回归系数方面，生物效应与体内暴露之间的关联在暴露低于中位数时通常更强。导致“正常”体内暴露水平的污染物环境暴露与体重指数存在相当大的差异有关。
