Biozentrum, University of Basel, Klingelbergstrasse 50/70, Basel, Switzerland.
J Cell Sci. 2011 Jan 15;124(Pt 2):171-80. doi: 10.1242/jcs.076455.
For growth, survival, communication and homeostasis, cells transport a large number of proteins to the plasma membrane and the extracellular medium by using the secretory pathway. Consequently, to adapt to the surrounding environment and the different intracellular contexts, the secretory pathway needs to accommodate and respond to a plethora of endogenous and exogenous stimuli. It is now well established that several kinases, known to be activated by environmental stimuli, signal from the plasma membrane to the secretory pathway in order to remodel its architecture and modulate the cellular secretion capacity. By contrast, membranes of the early secretory pathway, similar to the endosomal system, can also initiate and modulate signalling cascades, thereby spatially organising cellular signalling and eliciting a different cellular outcome than when signalling is localised to the plasma membrane. This Commentary highlights recent contributions to our understanding of the mutual regulation of the secretory pathway and cellular signalling.
为了生长、存活、通讯和维持体内平衡，细胞通过分泌途径将大量蛋白质运输到质膜和细胞外介质。因此，为了适应周围环境和不同的细胞内环境，分泌途径需要适应和响应大量的内源性和外源性刺激。现在已经明确，几种激酶，已知可被环境刺激激活，从质膜向分泌途径发出信号，以重塑其结构并调节细胞分泌能力。相比之下，早期分泌途径的膜，类似于内体系统，也可以启动和调节信号级联反应，从而在空间上组织细胞信号，并引发与信号局限于质膜时不同的细胞结果。本评论强调了最近对我们理解分泌途径和细胞信号之间相互调节的贡献。
