Adachi K, Chole R A
Department of Otolarygology, University of California, Davis, School of Medicine.
Ann Otol Rhinol Laryngol. 1990 Sep;99(9 Pt 1):738-41. doi: 10.1177/000348949009900914.
We hypothesized that bisphosphates, a class of antiosteolytic drugs that affect bone cells, may block localized bone modeling in the middle ear. Prior studies have shown that transmitted pressure in the middle ear leads to osteoclastic bone resorption. Catheters were surgically implanted into the middle ear cavity (bulla) of 31 Mongolian gerbils. The animals were then divided into two groups, one subset receiving a bisphosphonate, and the other receiving no drug. Positive air pressure was applied to one middle ear, and the other side served as a control. At the end of the experimental period, tissue specimens were obtained, and histomorphometric evaluation of the ventral bullae was performed. Significant differences in osteoclast surface, osteoclast number, and mean individual osteoclast profile area led us to conclude that administration of the bisphosphonate used at the dose studied inhibits localized recruitment and activation of osteoclasts.
我们推测，双膦酸盐类药物（一类影响骨细胞的抗骨吸收药物）可能会阻断中耳局部的骨重塑。先前的研究表明，中耳传递的压力会导致破骨细胞性骨吸收。通过手术将导管植入31只蒙古沙鼠的中耳腔（鼓泡）。然后将动物分为两组，一组接受双膦酸盐治疗，另一组不接受药物治疗。向一侧中耳施加正气压，另一侧作为对照。在实验期结束时，获取组织标本，并对腹侧鼓泡进行组织形态计量学评估。破骨细胞表面、破骨细胞数量和单个破骨细胞平均轮廓面积的显著差异使我们得出结论，在所研究的剂量下使用双膦酸盐给药可抑制破骨细胞的局部募集和激活。
