Chole R A
Department of Otolaryngology, University of California, Davis.
Ann Otol Rhinol Laryngol. 1993 Aug;102(8 Pt 1):616-9. doi: 10.1177/000348949310200809.
Osteoclast activation within the temporal bone leads to hearing loss in a variety of pathologic conditions, including otosclerosis, osteogenesis imperfecta, Paget's disease of bone, and chronic otitis media. Although endochondral (EC) bone is remodeled in these diseases, it is relatively more resistant to remodeling when compared to intramembranous (IM) bone. In this study, localized bone resorption and remodeling were induced on the inner surface of the middle ear by pressurization with air to 10 mm Hg above atmospheric. Osteoclast surface increased in IM bone, but not in EC bone. This study supports the concept that there may be fundamental differences between EC and IM bone and that EC is more resistant to pressure-induced localized resorption than IM bone.
颞骨内的破骨细胞激活会在多种病理状况下导致听力损失，这些病理状况包括耳硬化症、成骨不全症、佩吉特骨病和慢性中耳炎。尽管在这些疾病中软骨内（EC）骨会发生重塑，但与膜内（IM）骨相比，它对重塑的抵抗力相对更强。在本研究中，通过将空气压力升至高于大气压10毫米汞柱，在中耳内表面诱导局部骨吸收和重塑。IM骨中的破骨细胞表面增加，但EC骨中没有。本研究支持这样一种观点，即EC骨和IM骨之间可能存在根本差异，并且EC骨比IM骨对压力诱导的局部吸收更具抵抗力。
