Institute of Digital Medicine, Stuttgart, Germany.
Anticancer Res. 2010 Dec;30(12):5137-44.
Treatment decisions in breast cancer depend on TNM classification and the assessment of additional variables with have an impact on survival. We examined whether histological subtyping breast cancer as either ductal or lobular is related to disease outcome.
We examined a large data base of 14198 breast cancer patients.
Histological sub-classification of invasive breast cancer as either ductal or lobular is not correlated with disease outcome. However, the data further showed that invasive lobular carcinomas have a higher probability of being oestrogen receptor (ER)- and progesterone receptor (PR)-positive and a lower probability of being c-erbB2-positive. They also showed a higher average age at the time of diagnosis in comparison with invasive ductal carcinoma. Local recurrence rates were lower in invasive lobular carcinoma in comparison with invasive ductal carcinoma (3.5% vs. 6.2%; p = 0.031). The multivariable Cox regression analysis showed that ER, PR, nodal status, grade and tumour size predicted disease outcome with statistical significance, while the histological subtype (invasive ductal or lobular) was not a significant predictor of disease outcome.
Histological sub-classification of invasive breast cancer as either ductal or lobular is not correlated with disease outcome. On the other hand our data gives some indication that lobular and ductal breast cancer appear to be different biological entities.
乳腺癌的治疗决策取决于 TNM 分类以及对生存有影响的其他变量的评估。我们研究了乳腺癌的组织学亚型（导管或小叶）是否与疾病结局相关。
我们检查了 14198 例乳腺癌患者的大型数据库。
浸润性乳腺癌的组织学亚分类为导管或小叶与疾病结局无关。然而，数据进一步表明，浸润性小叶癌更有可能是雌激素受体（ER）和孕激素受体（PR）阳性，而 c-erbB2 阳性的可能性较低。与浸润性导管癌相比，它们在诊断时的平均年龄也更高。与浸润性导管癌相比，浸润性小叶癌的局部复发率较低（3.5%比 6.2%；p=0.031）。多变量 Cox 回归分析显示，ER、PR、淋巴结状态、分级和肿瘤大小与疾病结局具有统计学意义，而组织学亚型（浸润性导管或小叶）不是疾病结局的显著预测因素。
浸润性乳腺癌的组织学亚分类为导管或小叶与疾病结局无关。另一方面，我们的数据表明，小叶癌和导管癌似乎是不同的生物学实体。
