Miller M E, Scott T M
Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
Artery. 1990;17(5):233-47.
We have examined the effect of perivascular denervation on the ability of acetylcholine to produce endothelium-dependent relaxation in the isolated perfused mesenteric arterial bed. Treatment with capsaicin prevented the development of substance P and calcitonin gene-related peptide containing perivascular nerve fibres. Treatment with 6-hydroxydopamine prevented the development of catecholaminergic perivascular nerve fibres. In the arterial beds from capsaicin treated rats there was a depression of the ability of Acetylcholine to produce endothelium dependent relaxation. No change in endothelium-dependent relaxation to ACh was found in 6-hydroxydopamine treated rats.
我们研究了血管周围去神经支配对乙酰胆碱在离体灌注肠系膜动脉床中产生内皮依赖性舒张能力的影响。用辣椒素处理可阻止含P物质和降钙素基因相关肽的血管周围神经纤维的发育。用6-羟基多巴胺处理可阻止儿茶酚胺能血管周围神经纤维的发育。在辣椒素处理的大鼠的动脉床中，乙酰胆碱产生内皮依赖性舒张的能力有所降低。在6-羟基多巴胺处理的大鼠中，未发现对乙酰胆碱的内皮依赖性舒张有变化。
