Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
J Occup Environ Med. 2011 Jan;53(1):17-21. doi: 10.1097/JOM.0b013e3182028d20.
To investigate acute changes in circulating lipids after exposure to relatively high levels of particulate matter through welding.
Using a repeated measures panel study, lipid levels before and after welding and personal exposures to fine particulate matter (PM2.5) were measured in 36 male welders over 63 exposure and/or control days.
There was a trend toward decrease in HDL (-2.3 mg/dL, P = 0.08) 18 hours after welding. This effect became significant (-2.6 mg/dL, P = 0.05) after adjustment for possible confounders. The effect was strongest (-4.3 mg/dL, P = 0.02) among welders who did not weld the day before the study. There were no significant changes in other lipids associated with welding or PM2.5 exposure.
Welding exposure was associated with an acute decrease in circulating HDL, which may relate to the inflammatory and proatherosclerotic effects of fine particle exposure.
通过焊接研究暴露于相对高水平的颗粒物后循环脂质的急性变化。
使用重复测量面板研究，在 63 个暴露日和/或对照组中，对 36 名男性焊工进行焊接前后的血脂水平以及个人细颗粒物（PM2.5）暴露的测量。
焊接后 18 小时，HDL 呈下降趋势（-2.3mg/dL，P=0.08）。经过可能的混杂因素调整后，这种影响具有统计学意义（-2.6mg/dL，P=0.05）。在研究前一天没有焊接的焊工中，这种影响最强（-4.3mg/dL，P=0.02）。与焊接或 PM2.5 暴露相关的其他脂质没有显著变化。
焊接暴露与循环 HDL 的急性下降有关，这可能与细颗粒暴露的炎症和动脉粥样硬化作用有关。
