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硫化氢——一种强效多通道抗心律失常药物。

Hydrogen Sulfide-a potent multichannel anti-arrhythmic drug.

作者信息

Zhong Guang-Zhen

机构信息

Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China 100020

出版信息

J Cardiovasc Dis Res. 2010 Jan;1(1):37-9. doi: 10.4103/0975-3583.59984.

Abstract

-Arrhythmia is a big headache for cardiologist for a long time. A new antiarrythmic drug with good effects and few side effects should be explored. Hydrogen sulfide, a newly found gaseous transmitter, was found to have multi-effects on a variety of ion channels. It may be a promising antiarrythmic drug. This article reviews the different effects of hydrogen sulfide on different ion channels.

摘要

心律失常长期以来一直是心脏病专家的一大难题。应该探索一种疗效好、副作用少的新型抗心律失常药物。硫化氢是一种新发现的气体递质,被发现对多种离子通道有多种作用。它可能是一种有前景的抗心律失常药物。本文综述了硫化氢对不同离子通道的不同作用。

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H(2)S and HS(-) donor NaHS inhibits intracellular chloride channels.
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