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硫化氢——一种强效多通道抗心律失常药物。

Hydrogen Sulfide-a potent multichannel anti-arrhythmic drug.

作者信息

Zhong Guang-Zhen

机构信息

Department of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P.R. China 100020

出版信息

J Cardiovasc Dis Res. 2010 Jan;1(1):37-9. doi: 10.4103/0975-3583.59984.

DOI:10.4103/0975-3583.59984
PMID:21188089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3004170/
Abstract

-Arrhythmia is a big headache for cardiologist for a long time. A new antiarrythmic drug with good effects and few side effects should be explored. Hydrogen sulfide, a newly found gaseous transmitter, was found to have multi-effects on a variety of ion channels. It may be a promising antiarrythmic drug. This article reviews the different effects of hydrogen sulfide on different ion channels.

摘要

心律失常长期以来一直是心脏病专家的一大难题。应该探索一种疗效好、副作用少的新型抗心律失常药物。硫化氢是一种新发现的气体递质,被发现对多种离子通道有多种作用。它可能是一种有前景的抗心律失常药物。本文综述了硫化氢对不同离子通道的不同作用。

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本文引用的文献

1
H(2)S and HS(-) donor NaHS inhibits intracellular chloride channels.
Gen Physiol Biophys. 2009 Jun;28(2):190-4. doi: 10.4149/gpb_2009_02_190.
2
Phenomics of cardiac chloride channels: the systematic study of chloride channel function in the heart.心脏氯离子通道的表型组学:心脏中氯离子通道功能的系统研究。
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Hydrogen sulfide evokes neurite outgrowth and expression of high-voltage-activated Ca2+ currents in NG108-15 cells: involvement of T-type Ca2+ channels.硫化氢可诱导NG108-15细胞的神经突生长和高电压激活的Ca2+电流表达:T型Ca2+通道的作用。
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Hydrogen sulphide is an inhibitor of L-type calcium channels and mechanical contraction in rat cardiomyocytes.硫化氢是大鼠心肌细胞中L型钙通道和机械收缩的抑制剂。
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Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels.硫化氢通过开放ATP敏感性钾通道在缺血再灌注损伤期间发挥心脏保护作用。
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Electrophysiological effects of hydrogen sulfide on guinea pig papillary muscles in vitro.
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Hydrogen sulfide facilitates carotid sinus baroreflex in anesthetized rats.硫化氢促进麻醉大鼠的颈动脉窦压力感受性反射。
Acta Pharmacol Sin. 2006 Mar;27(3):294-8. doi: 10.1111/j.1745-7254.2006.00269.x.
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Direct stimulation of K(ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells.外源性和内源性硫化氢对血管平滑肌细胞中K(ATP)通道的直接刺激作用。
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