Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Mod Rheumatol. 2011 Jun;21(3):309-12. doi: 10.1007/s10165-010-0389-0. Epub 2010 Dec 28.
Kaposi's sarcoma (KS) is a vascular lesion of low-grade malignant potential caused by the complex interactions between geographic, genetic, environmental, and immunological factors. We recently experienced a rare case of KS associated with rheumatoid arthritis in a patient receiving corticosteroids and tacrolimus; the KS demonstrated unusually aggressive clinical behavior. We herein report the details of the clinical course and discuss the possible contribution of corticosteroids and tacrolimus to the development of aggressive KS in the present case.
卡波西肉瘤（KS）是一种低度恶性潜能的血管病变，由地理、遗传、环境和免疫因素的复杂相互作用引起。我们最近遇到一例接受皮质类固醇和他克莫司治疗的类风湿关节炎患者并发卡波西肉瘤的罕见病例；该卡波西肉瘤表现出异常侵袭性的临床行为。我们在此报告该病例的临床经过细节，并讨论皮质类固醇和他克莫司在该病例中导致侵袭性卡波西肉瘤发展的可能作用。
