杂草花粉诱导的变应性鼻炎患者的特异性IgE反应模式。

The specific IgE reactivity pattern of weed pollen-induced allergic rhinitis patients.

作者信息

Han Demin, Lai Xuxin, Gjesing Birgitte, Zhong Nanshan, Zhang Luo, Spangfort Michael D

机构信息

Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Beijing Institute of Otolaryngology, Capital Medical University, No. 17 HouGouHuTong, Beijing, China.

出版信息

Acta Otolaryngol. 2011 May;131(5):533-8. doi: 10.3109/00016489.2010.539265. Epub 2010 Dec 28.

DOI:10.3109/00016489.2010.539265

PMID:21189055

Abstract

CONCLUSION

Specific immunoglobulin E (IgE) reactivity towards the major mugwort allergen Art v 1 is a good indicator for Art v sensitization. Allergens from the ragweed species Amb t and Amb a possibly share common IgE-binding epitopes.

OBJECTIVE

The aim of this study was to investigate the reactivity pattern of IgE in Chinese patients with weed pollen-induced allergic rhinitis.

METHODS

Sera from 50 weed pollen-induced allergic rhinitis patients were tested for specific serum IgE reactivity against allergenic extracts of mugwort (Artemisia vulgaris, Art v), short ragweed (Ambrosia artemisiifolia, Amb a), giant ragweed (Ambrosia trifida, Amb t), and single allergens of Art v 1, Art v 3, Amb a 1, and profilin.

RESULTS

Sera from 88% of the patients demonstrated positive specific IgE reactivity to Art v, and of these 82% were positive to Art v 1. Sera from 38% of the patients showed positive specific IgE reactivity to both ragweed species Amb t and Amb a. A strong correlation was found between the specific IgE levels of Amb t and Amb a. Of the Amb a IgE-positive patients, 38% were positive for Amb a 1. Of all patient sera tested, 12% were specific IgE-positive to profilin.

摘要

结论

针对主要艾蒿过敏原Art v 1的特异性免疫球蛋白E（IgE）反应性是艾蒿致敏的良好指标。豚草属的过敏原Amb t和Amb a可能具有共同的IgE结合表位。

目的

本研究旨在调查中国杂草花粉诱导的变应性鼻炎患者中IgE的反应模式。

方法

检测50例杂草花粉诱导的变应性鼻炎患者血清中针对艾蒿（艾蒿，Art v）、豚草（豚草，Amb a）、三裂叶豚草（三裂叶豚草，Amb t）以及Art v 1、Art v 3、Amb a 1和肌动蛋白单体结合蛋白等单一过敏原提取物的特异性血清IgE反应性。

结果

88%的患者血清对Art v表现出阳性特异性IgE反应性，其中82%对Art v 1呈阳性。38%的患者血清对豚草属的Amb t和Amb a均表现出阳性特异性IgE反应性。发现Amb t和Amb a的特异性IgE水平之间存在强相关性。在Amb a IgE阳性患者中，38%对Amb a 1呈阳性。在所有检测的患者血清中，12%对肌动蛋白单体结合蛋白呈特异性IgE阳性。