Department of Otorhinolaryngology, Head and Neck Surgery, University of Goettingen, Robert-Koch-Strasse 40, Goettingen, Germany.
Am J Rhinol Allergy. 2012 Jan-Feb;26(1):31-5. doi: 10.2500/ajra.2012.26.3698.
Differential diagnosis between ragweed and mugwort pollen allergy represents a large clinical problem in areas where both plants are present. The aim of this study was to investigate ragweed- and mugwort-sensitized patients to identify specific IgE reactivity profiles. Results were correlated to clinical findings such as medical history and health-related quality of life (HRQL).
Seventy-four patients with allergic rhinoconjunctivitis between July and October were examined and underwent in vivo tests (skin-prick test [SPT] and nasal provocation). Sera were evaluated for IgE reactivity to mugwort and ragweed pollen extracts, major (Art v 1; Amb a 1) and minor (profilin and calcium-binding protein) allergens. HRQL was evaluated using a standardized questionnaire.
Seventy-one patients revealed positive SPT reactivity against mugwort and 60 patients against ragweed extracts. Of these patients, 74 revealed IgE antibodies against mugwort extracts, whereas anti-Art v 1 antibodies were detectable in 50 individuals. Fifty-five patients showed IgE antibodies against natural ragweed extracts; anti-Amb v 1 antibodies were detected in six cases only. Using standardized clinical history and HRQL questionnaires we were not able to detect any differences within different reactivity patterns.
Within the investigated population of 74 weed-allergic patients the prevalence of true mugwort and ragweed sensitization can be calculated as 68 and 8%. High prevalence of ragweed sensitization when testing with full extracts can be explained by cross-reactivity between other weeds, e.g., mugwort rather than cosensitization. Differences in medical history and HRQL between different reactivity patterns were not detectable.
豚草和艾蒿花粉过敏的鉴别诊断在这两种植物都存在的地区是一个很大的临床问题。本研究的目的是调查豚草和艾蒿致敏患者，以确定特异性 IgE 反应谱。结果与临床发现相关，如病史和健康相关生活质量（HRQL）。
7 月至 10 月间，对 74 例过敏性鼻结膜炎患者进行了检查和体内测试（皮肤点刺试验[SPT]和鼻激发试验）。评估血清对艾蒿和豚草花粉提取物、主要（Art v 1；Amb a 1）和次要（原肌球蛋白和钙结合蛋白）过敏原的 IgE 反应性。使用标准化问卷评估 HRQL。
71 例患者对艾蒿 SPT 反应呈阳性，60 例对豚草提取物呈阳性。在这些患者中，74 例对艾蒿提取物显示 IgE 抗体，而 50 例对 Art v 1 抗体有反应。55 例患者对天然豚草提取物显示 IgE 抗体；仅在 6 例中检测到抗 Amb v 1 抗体。使用标准化的临床病史和 HRQL 问卷，我们无法在不同的反应模式中检测到任何差异。
在所研究的 74 例杂草过敏患者人群中，真正的艾蒿和豚草致敏的患病率可计算为 68%和 8%。在使用全提取物进行测试时，豚草致敏的高患病率可以用其他杂草（如艾蒿）之间的交叉反应来解释，而不是共致敏。不同反应模式之间的病史和 HRQL 差异无法检测到。
