Nanoscale Organisation and Dynamics Group, School of Biomedical and Health Sciences, College of Health and Science, University of Western Sydney, Locked Bag 1797, Penrith South DC, 1797 NSW, Australia.
Curr Top Med Chem. 2011;11(5):521-42. doi: 10.2174/156802611794785226.
With an ageing baby-boomer population in the Western World, cancer is becoming a significant cause of death. The prevalence of cancer and all associated costs, both in human and financial terms, drives the search for new therapeutic drugs and treatments. Platinum anticancer agents, such as cisplatin have been highly successful but there are several disadvantages associated with their use. What is need are new compounds with different mechanisms of action and resistance profiles. What needs to be recognised is that there are many other metal in the periodic table with therapeutic potential. Here we have highlighted metal complexes with activity and have illustrate the different approaches to the design of anticancer complexes.
随着西方世界老龄化的婴儿潮一代人口的增加，癌症成为了一个重要的死亡原因。癌症的流行以及所有与之相关的人力和财力成本，促使人们不断寻找新的治疗药物和治疗方法。铂类抗癌药物，如顺铂，已经非常成功，但它们的使用也存在一些缺点。我们需要的是具有不同作用机制和耐药谱的新化合物。需要认识到，周期表中有许多其他金属具有治疗潜力。在这里，我们重点介绍了具有活性的金属配合物，并说明了设计抗癌配合物的不同方法。
