Dvořáková M, Paduchová Z, Muchová J, Duračková Z, Collins A R
Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Prague Med Rep. 2010;111(4):263-71.
Our purpose in this randomized, double blind, placebo controlled study was to find out the possible effect of a polyphenolic pine bark extract, Pycnogenol® (Pyc) on the level of 8-oxo-7,8-dihydroguanine (8-oxoG) as representative of oxidative damage to DNA and on the DNA repair ability of elderly people. According to our results, three months of Pyc administration had no effect on the level of oxidative damage to DNA or on repair ability, but we found a relationship between the level of 8-oxoG and repair ability of DNA in this group. To conclude, even if the positive effect of Pyc was not confirmed in the case of elderly people it is important to highlight the necessity of further investigations about the mechanisms of Pyc acting on different age groups.
在这项随机、双盲、安慰剂对照研究中，我们的目的是探究一种多酚类松树皮提取物碧萝芷（Pycnogenol®，简称Pyc）对作为DNA氧化损伤标志物的8-氧代-7,8-二氢鸟嘌呤（8-oxoG）水平以及老年人DNA修复能力的可能影响。根据我们的研究结果，连续三个月服用Pyc对DNA氧化损伤水平或修复能力均无影响，但我们发现该组中8-oxoG水平与DNA修复能力之间存在关联。总之，即便在老年人中未证实Pyc具有积极作用，但强调进一步研究Pyc作用于不同年龄组的机制的必要性仍很重要。
