Papadaki H I, Dimitracopoulos G, Bonicos D, Petrou G, Anastassiou E D
Department of Pathology, School of Medicine, University of Patras, Greece.
J Exp Pathol. 1990 Spring;5(1):7-18.
The time course of lesion development in mice induced by a single intraperitoneal (ip) LD50 dose of Pseudomonas aeruginosa slime glycolipoprotein (GLP) was studied. Slime GLP exerted a marked effect on the lungs, liver and kidneys without any microscopic changes in other organs. The first histological lesions were observed in the lungs 7h after ip injection and were characterized by thickening and pleomorphic inflammatory infiltration of the intraalveolar septae leading to focal atelectasis by 28 h. The initial morphological alterations in the liver were observed at 14 h and consisted of balloon degeneration of the hepatocytes, especially around the central veins, leading to fatty change within 21 h and confluent hepatocellular necrosis at 28 h. The kidneys showed hydropic degeneration of the renal tubular epithelial cells at 14 h and frank necrosis by 28 h post ip injection. The kidney and liver lesions were accompanied by a parallel rise in serum levels of blood urea nitrogen and aspartate and alanine aminotransferases.
研究了腹腔注射（ip）半数致死剂量（LD50）的铜绿假单胞菌黏液糖脂蛋白（GLP）诱导小鼠病变发展的时间进程。黏液GLP对肺、肝和肾有显著影响，而其他器官无任何微观变化。腹腔注射后7小时在肺中观察到首批组织学病变，其特征为肺泡间隔增厚和多形性炎性浸润，至28小时导致局灶性肺不张。肝脏的初始形态学改变在14小时观察到，表现为肝细胞气球样变性，尤其是中央静脉周围，至21小时导致脂肪变，28小时出现融合性肝细胞坏死。腹腔注射后14小时肾脏显示肾小管上皮细胞水样变性，28小时出现明显坏死。肾脏和肝脏病变伴随着血清中血尿素氮以及天冬氨酸和丙氨酸转氨酶水平的平行升高。
