Quatresooz P, Paquet P, Piérard G E
Service de Dermatopathologie, CHU de Liège, Belgique.
Rev Med Liege. 2010 Nov;65(11):619-22.
Actinic keratosis should no more be considered as a single neoplasm calling for an individual treatment. The concept of actinic photocarcinogenesis presently turns upside down the perception of skin cancers induced by nonionizing electromagnetic radiations. Currently, the clinician should cope with the whole skin area that has been damaged by chronic exposures to the visible and the invisible spectrum of the light. The therapeutic archetypes are 5-fluorouracile 5% and imiquimod 5% carefully applied to the skin area.
光化性角化病不应再被视为一种需要个体化治疗的单一肿瘤。目前,光化性光致癌作用的概念彻底颠覆了对非电离电磁辐射诱发皮肤癌的认知。目前,临床医生应应对因长期暴露于可见光和不可见光光谱而受损的整个皮肤区域。治疗的典型药物是仔细涂抹于皮肤区域的5%氟尿嘧啶和5%咪喹莫特。