Wang Yu-ping, Guo Chang-jiang, Yang Ji-jun, Wei Jing-yu, Zhang Qi, Yan Xian-zhong
Institute of Health and Environmental Medicine, Academy of Military Medieal Sciences, Tianjin 300050, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009 May;25(2):177-80.
To explore the metabolic effects of acute hypoxia on mice plasma.
Fourteen mice were randomly divided into two groups: control and hypoxia group. The mice of hypoxia group were exposed to a simulated altitude of 6000 meters for 8 hours. Nuclear magnetic resonance spectrometer was used to identify the metabolic changes after acute hypoxia.
Compared with control, the most notable significantly after acute hypoxia exposure. remarkably and lactate increased metabolic changes in plasma were as follows: camrnitine decreased levels of lipids and pyruvate, alanine, taurine, Decreases in levels of beta-HB, ethanol glycerol, glutamate, glycine and serine, and increased choline, glucose, and glutamine were also observed in hypoxia group.
Significant changes in the plasma carbohydrate, lipid and amino acid profiles were observed following acute hypoxia, suggesting a hypoxia-induced alteration in energy and related substances metabolism.
探讨急性缺氧对小鼠血浆的代谢影响。
将14只小鼠随机分为两组：对照组和缺氧组。缺氧组小鼠暴露于模拟海拔6000米的环境中8小时。采用核磁共振波谱仪鉴定急性缺氧后的代谢变化。
与对照组相比，急性缺氧暴露后最显著的代谢变化如下：肉碱、β-羟基丁酸、乙醇、甘油、谷氨酸、甘氨酸和丝氨酸水平降低，脂质、丙酮酸、丙氨酸、牛磺酸水平降低，缺氧组还观察到胆碱、葡萄糖和谷氨酰胺水平升高。
急性缺氧后血浆碳水化合物、脂质和氨基酸谱发生显著变化，提示缺氧诱导能量及相关物质代谢改变。
