[Treatment effects of electroacupuncture on gentamycin ototoxicity and its mechanism in guinea pigs].

AIM

To investigate the effects of electroacupuncture on gentamycin (GE) ototoxicity in guinea pigs.

METHODS

Brainstem auditory evoked potential (BAEP) and histochemistry were used in our study.

RESULTS

Electroacupuncture reduced the elevated BAEP thresholds and shortened the prolongated BAEP wave latencies and interpeak latencies. It protected the activity of mitochondrial enzyme in the cochlear hair cells and cochlear stria vascularis.

CONCLUSION

Electroacupuncture therapy can reduce GE ototoxicity. The mechanism of electroacupuncture therapy may be associated with its protected activity of mitochondrial enzyme and maintenance of energy metabolism of the cochlear hair cells and cochlear stria vascularis.