[Protective effect of ciliary neurotrophic factor against the ototoxicity of gentamicin in guinea pigs].

The effect of ciliary neurotrophic factor (CNTF) on gentamycin induced deafness was observed by Preyer's reflex, auditory brainstem evoked potential, bioelectric response of the cochlea and histomorphological examination of surface preparation of cochlea. It was found that CNTF was capable of reducing ototoxicity of gentamicin in guinea pigs, thus protecting hair cells of cochlea and auditory nerves.