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[一例发生于口腔的生殖器外子宫内膜异位症的免疫学方面]

[Immunological aspects of a case of extragenital endometriosis localized in the mouth].

作者信息

Akre D P, Konan K E, Seka S J, Dasse S R, Koffi K A, Abauleth R

机构信息

Dpt Immunologie, UFR Sciences Médicales Bouaké, Côte d'Ivoire.

出版信息

Odontostomatol Trop. 2010 Jun;33(130):15-20.

Abstract

To appreciate the role of the immune system in transportation and development of endometer cells in mouth, authors reported the results of immunological parameters analysis in one patient suffering to a mouth localisation healed endometriosis out of hormonal therapy in experimental and analytic study. Immunoglobulin A, G, M and C3, C4 complement fractions were measured by Mancini radial immunodiffusion. The count of CD4+, CD8+and B Cell was performed by BD FASCalibur flow cytometer. Autoimmune diseases were searched after by measuring autoantibodies using agglutination and immunofluoresence methods. The results showed any antibodies detected and the count of CD4, CD8 and B cells was normal. However, IgG and IgA increased. But C3, C4 factions and IgM decreased. This seems an immunological disorder which could be more explored in NK cells and cytokines study.

摘要

为了了解免疫系统在口腔子宫内膜细胞迁移和发育中的作用,作者在一项实验性和分析性研究中报告了一名口腔局部定位的子宫内膜异位症患者在接受激素治疗后痊愈的免疫参数分析结果。通过曼西尼放射免疫扩散法测定免疫球蛋白A、G、M以及C3、C4补体成分。采用BD FASCalibur流式细胞仪检测CD4 +、CD8 +和B细胞计数。通过凝集和免疫荧光法检测自身抗体以查找自身免疫性疾病。结果显示未检测到任何抗体,且CD4、CD8和B细胞计数正常。然而,IgG和IgA升高。但C3、C4成分和IgM降低。这似乎是一种免疫紊乱,在自然杀伤细胞和细胞因子研究中可能需要进一步探索。

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