解析 STAR 结构域蛋白识别 RNA 的结构基础。
Insights into the structural basis of RNA recognition by STAR domain proteins.
机构信息
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, LRB-906, Worcester, Massachusetts 01605, USA.
出版信息
Adv Exp Med Biol. 2010;693:37-53. doi: 10.1007/978-1-4419-7005-3_3.
Abstract
STAR proteins regulate diverse cellular processes and control numerous developmental events. They function at the post-transcriptional level by regulating the stability, sub-cellular distribution, alternative splicing, or translational efficiency of specific mRNA targets. Significant effort has been expended to define the determinants of RNA recognition by STAR proteins, in hopes of identifying new mRNA targets that contribute their role in cellular metabolism and development. This work has lead to the extensive biochemical characterization ofthe nucleotide sequence specificity of a handful of STAR proteins. In contrast, little structural information is available to analyze the molecular basis of sequence specific RNA recognition by this protein family. This chapter reviews the relevant literature on STAR domain protein structure and provides insights into how these proteins discriminate between different RNA sequences.
摘要
STAR 蛋白调节多种细胞过程，并控制许多发育事件。它们通过调节特定 mRNA 靶标的稳定性、亚细胞分布、选择性剪接或翻译效率，在转录后水平发挥作用。人们已经付出了巨大的努力来确定 STAR 蛋白对 RNA 的识别决定因素，以期确定新的 mRNA 靶标，以发挥其在细胞代谢和发育中的作用。这项工作已经对少数 STAR 蛋白的核苷酸序列特异性进行了广泛的生化特征描述。相比之下，关于该蛋白家族通过序列特异性 RNA 识别的分子基础，结构信息则非常有限。本章回顾了有关 STAR 结构域蛋白结构的相关文献，并深入探讨了这些蛋白如何区分不同的 RNA 序列。
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