病毒RNA-蛋白质复合物协同进化的结构基础。

Chao Jeffrey A, Patskovsky Yury, Almo Steven C, Singer Robert H

Department of Anatomy, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, USA.

Nat Struct Mol Biol. 2008 Jan;15(1):103-5. doi: 10.1038/nsmb1327. Epub 2007 Dec 9.

The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved beta-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

与特征明确的MS2外壳蛋白-RNA复合物相比，PP7噬菌体外壳蛋白与其翻译操纵子形成的共晶体结构确定了一种序列特异性RNA识别的独特模式。该结构揭示了PP7外壳蛋白选择性结合其同源RNA能力的分子基础，并表明保守的β-折叠表面是一种灵活的结构，能够进化以识别多种RNA发夹结构。