Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Adv Exp Med Biol. 2010;693:93-105.
Signal transduction and activation of RNA (STAR) family of RNA binding proteins are highly conserved through evolution indicating their core role during development, as well as in adult life. This chapter focuses on two Drosophila STAR proteins: held out wing (HOW), the ortholog of mammalian quaking (QKI) and Kep1, one of the four orthologs of mammalian Sam 68. I will emphasize the orthologs similarities in splicing pattern, functions and mode of actions of the two proteins relying on recent and earlier findings in the field. I will start with general description of the STAR proteins in Drosophila with an emphasis on their specific expression patterns.
信号转导和 RNA 激活 (STAR) 家族的 RNA 结合蛋白在进化过程中高度保守，这表明它们在发育过程中以及在成年生活中起着核心作用。本章重点介绍两种果蝇 STAR 蛋白：伸出的翅膀 (HOW)，与哺乳动物 quaking (QKI) 的同源物，以及 Kep1，哺乳动物 Sam 68 的四个同源物之一。我将强调这两种蛋白质在剪接模式、功能和作用方式上的同源物相似性，这依赖于该领域最近和早期的发现。我将从果蝇中 STAR 蛋白的一般描述开始，重点介绍它们的特定表达模式。
